· The tournament was expanded from 47 to 54 teams.
· A total of 44 teams would directly enter the Copa Sudamericana, while a total of 10 teams eliminated from the Copa Libertadores (two best teams eliminated in the third stage of qualifying and eight third-placed teams in the group stage) would be transferred to the Copa Sudamericana, entering the competition in the second stage.
· The schedule of the tournament was extended to year-round so it would start in February and conclude in December.
· As the Copa Libertadores and the Copa Sudamericana would be held concurrently, no team would be able to qualify for both tournaments in the same year (except those which were transferred from the Copa Libertadores to the Copa Sudamericana).
· The Copa Sudamericana champions would no longer directly qualify for the next edition as they would now directly qualify for the group stage of the Copa Libertadores (although they would still be able to defend their title if they finished third in the group stage).
· Brazil would be allocated six berths, decreased from eight.
· All teams directly entering the Copa Sudamericana would enter the first stage.
The competition\'s format was further altered ahead of the 2021 edition, in which a group stage was introduced replacing the second stage and the six qualifiers from Argentina and Brazil were given byes to that stage, with the teams from the remaining associations being drawn against a team from their same country in the first stage, ensuring that at least two teams from each association would take part in the group stage. The competition was further expanded to include all four teams eliminated from the Copa Libertadores third stage, which would also enter the group stage, while the eight third-placed teams from the Copa Libertadores group stage would enter the round of 16. Two years later, the format for the first stage of the tournament was changed from double-legged ties to single-match ones and a knockout round prior to the round of 16 was introduced, in which the eight teams transferred from the Copa Libertadores group stage would play against the Copa Sudamericana group runners-up with the winners joining the group winners in the following stage of the competition.